富硒酵母与TACE治疗原发性肝癌临床疗效及安全性.doc

富硒酵母与TACE治疗原发性肝癌临床疗效及安全性
[摘要] 目的 观察富硒酵母与经肝动脉化疗栓塞术(TACE)治疗原发性肝癌的临床疗效并评价其应用安全性。方法 选择我院2016年11月~2018年5月收治的89例原发性肝癌患者). The VEGF level in the observation group after treatment was significantly higher than that before treatment, the difference was statistically significant (P<), and was significantly lower than that of the control group after treatment and the difference was statistically significant(P<). KPS score: There was no significant difference between the two groups before treatment(P>). After treatment, the decrease of the observation group was lower than that of the control group, and the difference was statistically significant(P<). Adverse reactions: There was no significant difference between the control group and the observation group(P>). Conclusion Selenium-enriched yeast combined with TACE in the treatment of primary liver cancer can effectively improve the selenium level in patients, inhibit serum VEGF level, and control tumor progression, with no serious adverse reactions and high safety, which is worthy of clinical application. [Key words] Selenium-enriched yeast; Transcatheter arterial chemoembolization; Primary liver cancer; Safety
原发性肝癌系指原发于肝细胞或肝内胆管上皮细胞的恶性肿瘤,为临床最常见恶性肿瘤之一[1],因其起病隐匿性较强,潜伏期长,发展速度快,恶性程度高,容易侵袭与发生转移,临床预后差,患者往往在确诊后只有很短的生存期。外科手术是治疗原发性肝癌的主要手段与措施[2],但早期症状不明显,很难做到早发现早治疗,虽然近些年针对高危人群与普通人群改进了筛查方法,提升了早期发现率,但是手术效果依然还有待提升,且术后并发症及高复发率也限制了手术的临床应用。因此,针对无法手术的患者只能通过化学治疗、介入治疗、放射治疗、免疫治疗来改善其临床症状,提升生存质量,延长生存期[3]。经肝动脉化疗栓塞术(Transhepatic arterial chemoembolization,TACE)是当前公认的非手术治疗原发性肝癌的首选治疗方法,其具有微创、靶向性高等优势,能够对肿瘤发展起到良好的抑制作用。但TACE治疗方法依然存在一定禁忌证,且对肝癌无法起到根治效果,复发率较高,因此,当前一般均采用联合应用其他治疗方法。
1 资料与方法
一般资料
选择我院2016年11月~2018年5月收治的89例原发性肝癌患者为本次研究对象,按照患者入院后病床单双号分为单号45例为对照组,双号44例为观察组。对照组中,男31例,女14例;年龄36~71岁,平均(±)岁。观察组中,男32例,女12例;年龄34~72岁,平均(±)岁。两组患者一般资料比较,差异无统计学意义(P>)。
纳入与排除标准
纳入标准:①经过病理组织学确诊的原发性肝癌患者;②患者甲胎蛋白(Alpha fetoprotein,AFP)≥400 μg/L时间超过1个月或AFP≥200 μg/L时间超过2个月者;③存在明显手术禁忌或拒绝接受手术治疗者;④经确诊未发现肝