高灵敏乙肝病毒检测的临床意义.docx

高灵敏乙肝病毒检测的临床意义
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临床论著·
高灵敏度HBV DNA 检测指导慢性乙型肝炎患者抗病毒治疗的临床意义
邵国辉 闫香芹 陈合民 张雷 孙敏 孙瑜
目的 探讨高灵敏度HB higher than the high sensitive HBV DNA detection line (20 IU/ml). And 73 (%) cases of the withdrawal group were detected than 20 IU/ml; in the treatment group, 19 cases were detected higher than 103 IU/ml, 43 (%) cases were detected ≥ 20 IU/ml in quasi treatment group. There was a significant positive correlation between different HBV DNA load groups by COBAS reagent detection and HBsAg concentration logarithm value (P ＜ ). Conclusions High sensitive quantitative PCR should be furtherly conducted for HBV DNA low load patients to guide the initial application or discontinuation of nucleos(t)ide drugs.


Hepatitis B virus; Fluorescence quantitative PCR; COBAS Amplicor system; Clinical application
DOI ：.-1358. 2022. 01. 010
基金项目：山东省济宁市科技项目编号（No. 2022jnnk09）作者单位：273031 济宁市，山东省济宁市传染病医院一病区通讯作者：邵国辉，Email ：******@ 为探求核苷（酸）类药物安全停药的相关指标，本研究对于国产试剂HBV DNA 低于检测下限的慢性乙型肝炎（chronic hepatitisB ，CHB ）患者在停


药前进行了高灵敏HBV DNA 检测。在研究过程中，发现应用COBAS Amplicor 系统检测高灵敏HBV DNA 对于HBV DNA 低载量CHB 患者更具意义。为探讨高灵敏HBV DNA 检测在HBV DNA 低载量患者中的应用，本研究对160例应用国产试剂检测H