替加环素致低纤维蛋白原血症与血药浓度的相关性 金路.pdf

: .
医药导报
素谷浓度（Cmin）、峰浓度（Cmax）和 24 h 浓度-
时间曲线下面积（AUC0-24）均差异有统计学意义（均
P<）。通过 ROC 曲线得到替加环素导致低纤维蛋
白原血症的折点为 Cmin= .mL-1 ，
-1
AUC0-24= ·h .mL 。结论 替加环素血药浓度与
导致低纤维蛋白原血症有关。临床在应用替加环素治疗重症感染时，一方面要考虑疗效，另一方面也不能
忽视替加环素可能导致的不良反应，有必要定期进行
血药浓度监测。
关键词 替加环素；浓度-毒性关系；低纤维蛋白原
血症；治疗药物监测

Research on Correlation Between Tigecycline-induced
Hypofibrinogenemia and Concentration
JIN Lu1,2，LUO Xuemei1，YANG Xiaoxuan3，ZHU
Huaijun1，GE Weihong1
（ of Medication，Affiliated Drum
Tower Hospital of Nanjing University Medical School，
Nanjing 210008，China；2. Nanjing Medical Center for
Clinical Pharmacy，Nanjing 210008，China；3. Nanjing
Drum Tower Hospital of China Pharmaceutical
University，Nanjing 210008，China）
ABSTRACT Objective： To determine the existence
of correlation between tigecycline-induced
hypofibrinogenemia and concentration and define
thresholds above which toxicity is more likely.
Methods： Patients receiving tigecycline from April
2019 to April 2021 were retrospectively analyzed, andthe concentration of tigecycline, fibrinogen（FIB）values
and other clinical indicators were recorded before and
after treatment, and the patients were classified into
adverse drug reaction（ADR）group and control group
according to the criteria. The difference in tigecycline
concentration between the two groups was analyzed and
the cut-off of ADR was obtained by ROC ：
123 patients were enrolled according to the criteria, and
there was no statistical difference in age, gender, dose,
course of treatment and other clinical characteristics
between ADR group and control group. There were
significant differences in tigecy