胃癌患者血清胰岛素样生长因子-Ⅱ检测及其临床意义.doc

1 胃癌患者血清胰岛素样生长因子- Ⅱ检测及其临床意义作者:卢圣爱陈自平刘倩徐昌青贾欣永郭荣【摘要】目的: 探讨胰岛素样生长因子-Ⅱ( IGF- Ⅱ) 与胃癌的关系。方法: 采用放射免疫法对 31 例胃癌患者血清 IGF- Ⅱ水平进行检测,并与 10 例正常组、 10 例慢性萎缩性胃炎伴肠腺化生( CAGGM ) 组及 10 例慢性萎缩性胃炎伴重度不典型增生( CAGD ) 组作对照。比较 20 例胃癌患者手术前后血清 IGF- Ⅱ水平的变化, 分析其与胃癌病理分期、恶性程度、肝转移及与幽门螺旋杆菌( Hp ) 感染的关系。结果: 血清 IGF- Ⅱ水平胃癌组和 CAGD 组较正常组均明显升高( , ) ,且胃癌组较 CAGGM 组、 CAGD 组血清升高( , ), CAGD 组与 CAGGM 组比较亦有显著性差异( ); 术后 2 周血清 IGF- Ⅱ水平较术前显著下降( ) 。中、晚期胃癌患者血清 IGF- Ⅱ水平较早期患者显著升高( ); 差分化型胃癌患者血清 IGF- Ⅱ水平较分化型明显升高( ) ;胃癌有无肝转移、是否伴 Hp 感染其血清 IGF- Ⅱ水平均无明显差异。结论: 血清 IGF- 2 Ⅱ水平升高是胃癌发生、发展的重要因素之一; 检测血清 IGF- Ⅱ水平的变化,对胃癌的诊断、手术切除是否彻底、判断病情变化有一定临床价值。 Hp 感染与血清 IGF- Ⅱ水平升高可能分别作为独立因素,共同参与胃癌的发生、发展。【关键词】胃肿瘤胰岛素样生长因子-Ⅱ Detection and clinical significance of serum insulin growth factor- Ⅱ in patients with gastric carcinoma 【 ABSTRACT 】 Objective: To investigate the relationship between the serum insulin growth factor- Ⅱ(IGF- Ⅱ) and gastric carcinoma (GC). Methods: Levels of serum IGF- Ⅱ was detected by radioimmunoassay in 31 cases of GC, 10 cases of chronic atrophic gastritis glandular metaplasia (CAGGM), 10 cases of chronic atrophic gastritis dysplasia (CAGD), and 10 age-matched healthy controls. The variation of serum IGF- Ⅱ pared in 20 cases of GC. The relationship between variation of serum IGF- Ⅱ with ic condition, malignancy degree, liver metastasis and helicobacter pylori (Hp) infection of GC were analyzed. Results: Serum levels IGF- Ⅱ in GC group and CAGD group increased significantly higher than 3 those in healthy controls (, ). There was significant difference between CAGGM group and CAGD group (). Two weeks after operation, IGF- Ⅱ was decreased significantly (). IGF- Ⅱ was elevated in mid-advanced carcinoma of stomach than those in early stage (), and it was increased in undifferentiatial type patients than that of differentiatial type patients (). No differences were found in the patients with liver metastasis and Hp infection. Conclusion: The elevation of