11 大型蚤，麦格纳.pdf

ARTICLE IN PRESS
Ecotoxicology and Environmental Safety 69 (2008) 428–436
ate/ecoenv
Mixture toxicity of three toxicants with similar and dissimilar modes of
action to Daphnia magna
Kristian Syberga,1, Anders Ellebyb,Ã,1, Henrik Pedersena, Nina Cedergreenc, Valery E. Forbesa
aDepartment of Environmental, Social and Spatial Change, Roskilde University, Universitetsvej 1, 4000 Roskilde, Denmark
bDepartment of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, 2860 , Denmark
cDepartment of Agricultural Sciences, Faculty of Life Science, University of Copenhagen, Højbakkega˚rd Alle´ 13, 2630 Taastrup, Denmark
Received 23 May 2006; received in revised form 9 March 2007; accepted 3 May 2007
Available online 12 July 2007
Abstract
Mixture toxicity of similar- and dissimilar-acting toxicants can be predicted by the models concentration addition (CA) and
independent action (IA) using single substance toxicity data. Knowledge of the toxicants mode of action is thus required in order to use
the models. In order to test the predictive capability of the models, we conducted Daphnia magna 48 h immobilization experiments with
three toxicants with known modes of action (dimethoate, pirimicarb and linear alkyl benzene sulfonate) singly, and in binary and ternary
mixtures. Our results indicate that CA and IA predict