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中南大学学报(医学版)
2004 ,29 (5)
576 J Cent South Univ(Med Sci)
能带来的全身毒性作用。此外,骨髓单个核细胞还[5 ] Hamano K ,Li TS , Kobayashi T ,et al. The induction of angiogene
可作为促血管新生各种基因治疗的释放载体。由3于 sis by the implantation of autologous 2bone2marrow cells : A novel
and simple therapeutic method[J ]. Surgery ,2001 ,130 (1) :44 53.
自身骨髓容易获取,分离骨髓单个核细胞操作简单,
[6 ] Kamihata H , Matsubara H , Nishiue T , et al. Implantation of
因此以局部植入骨髓单个核细胞为基础的血运重
, 2 bone marrow mononuclear cells into ischemic myocardium enhances
建方法有重要的临床意义。 collateral perfusion and regional function viaside supply of an
骨髓单个核细胞促进血管再生的具体机制和安 gioblasts, angiogenic ligands , and cytokines [ J ]. Circulation ,
全性,植入细胞的最适时机、数量,促血管再生的远 2001 ,104 (9) :1046 1052.
[ 7 ] Fuchs S , Baffour R , Zhou L F , et al. Transendocardial delivery of
期效果以及在慢性缺血条件下的作用等尚需进一步
autologous bone marrow enhances collateral perfusion and regional
研究明确。
function in pigs with chronic experimental myocardium ischemia
( )
参考文献: [J ]. J Am Coll Cardiol , 2001 ,37 6 : 1726 1732.
2 2 2 [8 ] Asahara T , Murohara T , Sullivan A , et al. Isolat3ion of putative
2
[1 ] Kobayashi T , Hamano K , Li TS , et al. Enhancement of angio progenitor endothelial cells for angiogenesis [J ]. Science , 1997 ,
genesis by the implantation of self bone marrow cells in a rat is 275 (5302)
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