Activation of insulin-like growth factor receptor signaling mediates resistance to histone deacetylase inhibitors.pdf.pdf

ARTICLE IN PRESS
Cancer Letters ■■(2015) ■■–■■
Contents lists available at ScienceDirect
Cancer Letters
journal homepage: ate/canlet
Original Articles
Activation of insulin-like growth factor receptor signaling mediates
resistance to histone deacetylase inhibitors
Jin-Soo Kim a,1, Su-Chan Lee b, Hye-Young Min b, Kwan Hee Park b, Seung Yeob Hyun b,
So Jung Kwon c, Sun Phil Choi a, Woo-Young Kim a,2, Hyo-Jong Lee c, Ho-Young Lee b,*
a Department of Thoracic Head & Neck Medical Oncology, The University of Texas . Anderson Cancer Center, Houston, TX, United States
b College of Pharmacy, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of Korea
c College of Pharmacy, Inje University, Gimhae, Gyungnam 621-749, Republic of Korea
ARTICLE INFO ABSTRACT
Article history: Histone deacetylases (HDACs) are considered promising targets in the treatment of hematologic malig-
Received 27 October 2014 nancies and several types of solid tumors, including non-small cell lung cancer (NSCLC). However, the
Received in revised form 16 February 2015 efficacy of HDAC inhibitors in solid tumors is marginal, and the mechanisms underlying resistance to
Accepted 16 February 2015
HDAC inhibitors are largely unknown. Here, we demonstrate the involvement of type 1 insulin-like growth
factor receptor (IGF-1R) signaling in resistance to H