Association between insulin resistance and cognition in patients with depressive disorders Exploratory analyses into age-specific effects.pdf.pdf

Journal of Psychiatric Research 60 (2015) 65e72
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Journal of Psychiatric Research
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Association between insulin resistance and cognition in patients with
depressive disorders: Exploratory analyses into age-specific effects
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Tonita E. Wroolie, Heather A. Kenna, Manpreet K. Singh, Natalie L. Rasgon
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, USA
article info abstract
Article history: The current preliminary cross sectional study sought to examine the effects of insulin resistance (IR) and
Received 16 November 2013 body mass index (BMI) on cognitive performance in adult patients with a history depression, currently
Received in revised form not in an acute Major Depressive Episode (MDD). As an exploratory post hoc investigation, special
2 October 2014
consideration was given to adults <45 years and 45 years old.
Accepted 3 October 2014
Subjects included men and women ages 19-71 (N ¼ 39) with a history of a non-psychotic, non-
melancholic MDD. All subjects underwent an insulin suppression test to determine Steady-State Plasma
Keywords:
Glucose (SSPG), a battery of neuropsychological tests, and measurement of BMI. Multiple linear re-
Insulin resistance
Depression gressions were conducted to determine whether there were differential effects