Bioactives from Artemisia dracunculus L. enhance insulin sensitivity via modulation of skeletal muscle protein phosphorylation.pdf.pdf

Nutrition 30 (2014) S43–S51
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Nutrition
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Novel mechanisms for botanical effect
Bioactives from Artemisia dracunculus L. enhance
insulin sensitivity via modulation of skeletal muscle
protein phosphorylation
Indu Kheterpal . a, Peter Scherp . a, Lauren Kelley . a, Zhong Wang . b,
William Johnson . c, David Ribnicky . d, William T. Cefalu . b,*
a Protein Structural Biology and Proteomics and Metabolomics Core Facility, Pennington Biomedical Research Center, Louisiana State University
System, Louisiana, USA
b Diabetes and Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Louisiana, USA
c Biostatistics and Data Management, Pennington Biomedical Research Center, Louisiana State University System, Louisiana, USA
d Department of Plant Biology and Pathology, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA
abstract
Keywords: Objectives: A botanical extract from Artemisia dracunculus L., termed PMI 5011, has been shown to
Skeletal muscle improve insulin sensitivity by increasing cellular insulin signaling in in vitro and in vivo studies.
Insulin resistance These studies suggest that PMI 5011 effects changes in phosphorylation levels of proteins involved
Botanicals in insulin signaling. The aim of this study was