Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance.pdf.pdf

Article
Blocking IL-6 trans-Signaling Prevents High-Fat Diet-
Induced Adipose Tissue Macrophage Recruitment but
Does Not Improve Insulin Resistance
Graphical Abstract Authors
Michael J. Kraakman,
Helene L. Kammoun, ...,
Stefan Rose-John, Mark A. Febbraio
Correspondence
mark.******@
In Brief
Macrophage recruitment to adipose
tissue is a hallmark of obesity and can
contribute to insulin resistance.
Kraakman et al. show that IL-6 trans-
signaling is responsible for macrophage
recruitment to adipose tissue in obesity, a
process that can be blocked by treatment
with a soluble gp130Fc protein.
Highlights Accession Numbers
d IL-6 trans-signaling recruits macrophages to adipose tissue GSE6376
in HFD-induced obesity
d Blocking IL-6 trans-signaling with sgp130Fc prevents HFD-
induced ATM accumulation
d Prevention of ATM accumulation in obesity does not rescue
insulin resistance
d Blocking IL-6 trans-signaling does not exacerbate HFD-
induced insulin resistance
Kraakman et al., 2015, Cell Metabolism 21, 403–416
March 3, 2015 ª2015 Elsevier Inc.
http://dx./.
Cell Metabolism
Article
Blocking IL-6 trans-Signaling Prevents High-Fat
Diet-Induced Adipose Tissue Macrophage Recruitment
but Does Not Improve Insulin Resistance
Michael J. Kraakman,1 Helene L. Kammoun,1 Tamara L. Allen,1 Virginie Deswaerte,2 Darren C. Henstridge,1
Emma Estevez,1 Vance B. Matthews,1 Bronwyn Neill,1 David A. White,3 Andrew J. Murphy,4 Lone Peijs,1 Christine Yang,1
Steve Risis,1 Clinton R. Bruce,1 Xiao-Jun Du,3 Alex Bobik,2 Robert S. Lee-Young,1 Bronwyn A. Kingwell,5
Ajithkumar Vasanthakumar,6 Wei Shi,6,7 Axel Kallies,6 Graeme I. Lancaster,1 Stefan Rose-John,8 and Mark A. Febbraio1,*
1Cellular and Molecular Metabolism Laboratory
2Vascular Biology and Atherosclerosis Laboratory
3Experimental Cardiology Laboratory
4Haematopoiesis and Leukocyte Biology Laboratory
5Metabolic and Vascular Physiology Laborato