Ca2+ mishandling and cardiac dysfunction in obesity and insulin resistance Role of oxidative stress.pdf.pdf

Cell Calcium 56 (2014) 408–415

Contents lists available at ScienceDirect
Cell Calcium

jou rnal homepage: ate/ceca
Review
2+

Ca mishandling and cardiac dysfunction in obesity and insulin

resistance: Role of oxidative stress
a a,b b

Karla Carvajal , Jaime Balderas-Villalobos , Ma. Dolores Bello-Sanchez ,
a b b

Bryan Phillips-Farfán , Tzindilu Molina-Munoz˜, Hugo Aldana-Quintero ,
b,∗

Norma L. Gómez-Viquez
a

Laboratorio de Nutrición Experimental, Instituto Nacional de Pediatría, Mexico City, Mexico
b




Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados-Instituto ico Nacional, Mexico City, Mexico

a r t i c l e i n f o a b s t r a c t


Article history: Obesity and insulin resistance (IR) are strongly connected to the development of subclinical cardiac

Available online 10 August 2014

dysfunction and eventually can lead to heart failure, which is the main cause of morbidity and death

in patients having these metabolic diseases. It has been considered that excessive fat tissue may play
Keywords:


a critical role in producing systemic IR and enhancing reactive oxygen species (ROS) generation. This
Ca2+ handling

oxidative stress (OS) may elicit or exacerbate IR. On the other hand, evidence suggests that some of
Cardiomyopathy

the cellular mechanisms involv