Cortical thinning in type 2 diabetes mellitus and recovering effects of insulin therapy.pdf.pdf

Journal of Clinical Neuroscience 22 (2015) 275–279
Contents lists available at ScienceDirect
Journal of Clinical Neuroscience
journal homepage: ate/
Clinical Study
Cortical thinning in type 2 diabetes mellitus and recovering effects
of insulin therapy
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Zhiye Chen a, Jie Sun b, Yang Yang c, Xin Lou a, Yulin Wang a, Yan Wang a, Lin Ma a,
a Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
b Department of Endocrinology, Chinese PLA 89 Hospital, Weifang, Shandong, China
c Department of Neurology, Chinese PLA General Hospital, Beijing, China
article info abstract
Article history: The purpose of this study was to explore the brain structural changes in type 2 diabetes and the effect of
Received 3 September 2013 insulin on the brain using a surface-based cortical thickness analysis. High-resolution three-dimensional
Accepted 6 July 2014 T1-weighted fast spoiled gradient recalled echo MRI were obtained from 11 patients with type 2 diabetes
before and after insulin therapy. The cortical thickness over the entire brain was calculated, and cross-
sectional and longitudinal surface-based cortical thickness analyses were also performed. Regional corti-
Keywords: cal thinning was demonstrated in the middle temporal gyrus, posterior cingulate gyrus, precuneus, right
Brain
lateral occipital gyrus and entorhinal cortex bilat