Dietary nitrite supplementation improves insulin resistance in type 2 diabetic KKAy mice.pdf.pdf

Nitric Oxide 44 (2015) 31–38
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Nitric Oxide
journal homepage: ate/yniox
Dietary nitrite supplementation improves insulin resistance in type 2
diabetic KKAy mice
Kazuo Ohtake a, Genya Nakano a, Nobuyuki Ehara a, Kunihiro Sonoda b, Junta Ito c,
Hiroyuki Uchida a, Jun Kobayashi a,*
a Division of Pathophysiology, Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Science, Josai University, Saitama, Japan
b Department of Food and Nutritional Environment, College of Human Life and Environment, Kinjo Gakuin University, Nagoya, Japan
c Division of Oral Anatomy, Department of Human Development and Fostering, Meikai University School of Dentistry, Saitama, Japan
ARTICLE INFO ABSTRACT
Article history: Background: Because insulin signaling is essential for endothelial nitric oxide synthase (eNOS)-derived
Received 12 September 2014 nitric oxide (NO) production, the loss of bioavailable NO might be mon molecular mechanism un-
Revised 3 November 2014 derlying the development of insulin resistance and endothelial dysfunction. Although dietary nitrite acts
Available online 13 November 2014
as a substrate for systemic NO generation, thereby serving as a physiological alternative source of NO
for signaling, it is not precisely known how dietary nitrite affects type 2 diabetes mellitus. Here we report
Keywo