Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients.pdf.pdf

Journal of Diabetes and plications 29 (2015) 413–421
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Journal of Diabetes and plications
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Early phase glucagon and insulin secretory abnormalities, but not
incretin secretion, are similarly responsible for hyperglycemia after
ingestion of nutrients
Daisuke Yabe a,b,c,⁎, Akira Kuroe a,1, Koin Watanabe a, Masahiro Iwasaki b,c, Akihiro Hamasaki d,2,
Yoshiyuki Hamamoto d,2, Norio Harada d, Shunsuke Yamane d, Soushou Lee e, Kenta Murotani f,
Carolyn F. Deacon g, Jens J. Holst g, Tsutomu Hirano e, Nobuya Inagaki d, Takeshi Kurose a, Yutaka Seino a,⁎
a Center for Diabetes, Endocrinology, and Metabolism, Kansai Electric Power Hospital, 2-1-7 Fukushima-ku, Osaka 553–0003, Japan
b Center for Metabolism and Clinical Nutrition, Kansai Electric Power Hospital, 2-1-7 Fukushima-ku, Osaka 553–0003, Japan
c Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, 1-5-6 Minatojimaminamimachi, Chuo-ku,
Kobe 650–0047, Japan
d Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, 54 Shogo-in Kawahara-cho, Sakyo-ku, Kyoto 606–8507, Japan
e Department of Diabetes, Metabolism and Endocrinology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142–8555, Japan
f Center for Advanced