Extension of Drosophila lifespan by cinnamon through a sex-specific dependence on the insulin receptor substrate chico.pdf.pdf

Experimental Gerontology 60 (2014) 220–230
Contents lists available at ScienceDirect
Experimental Gerontology
journal homepage: ate/expgero
Extension of Drosophila lifespan by cinnamon through a sex-specific
dependence on the insulin receptor substrate chico
Samuel E. Schriner, Steven Kuramada, Terry E. Lopez, Stephanie Truong, Andrew Pham, Mahtab Jafari ⁎
Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697, USA
article info abstract
Article history: Cinnamon is a monly used worldwide to flavor desserts, fruits, cereals, breads, and meats. Numerous
Received 21 May 2014 health benefits have been attributed to its consumption, including the recent suggestion that it may decrease
Received in revised form 10 September 2014 blood glucose levels in people with diabetes. Insulin signaling is an integral pathway regulating the lifespan of
Accepted 13 September 2014
anisms, such as worms, flies, and mice. We posited that if cinnamon truly improved the clinical
Available online 16 October 2014
signs of diabetes in people that it would also act on insulin signaling in anisms and increase
fl
Section Seditor: . Johnson lifespan. We found that cinnamon did extend lifespan in the fruit y, Drosophila melanogaster. However, it had
no effect on the expression levels of the 3 aging-related Drosophila insulin-like peptides nor did it alter sugar,
Keywords: fat, or soluble protein levels, as would be predicted. In addition, cinnamon exhibited no protective effects in
Cinnamon males against oxidative challenges. However, in females it did confer a protective effect against paraquat, but
Botanical extract sensitized them to iron. Cinnamon provided no protective effect against ation and starvation in females,
Insulin signaling but sensitized males to both. Interestingly, cinnamon protected both sexes against cold, sensitized both to
Lifespan heat, and elevated HSP70 expression levels. We also found that cinnamon required the