Inhibition of human insulin gene transcription and MafA transcriptional activity by the dual leucine zipper kinase.pdf.pdf

Cellular Signalling 26 (2014) 1792–1799
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Cellular Signalling
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Inhibition of human insulin gene transcription and MafA transcriptional
activity by the dual leucine zipper kinase
Marie-te Stahnke a, Corinna Dickel a, Sabine Schröder b,DianaKaiserb,RolandBlumea, Roland Stein d,
Celio Pouponnot e,ElkeOetjena,b,c,f,⁎
a Department of Pharmacology, University Medical Center Göttingen, Göttingen, Germany
b Institute of Clinical Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
c DZHK (German Centre for Cardiovascular Research) partner site Hamburg/Kiel/Lübeck, Hamburg, Germany
d Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA
e Institut Curie, CNRS UMR 3347, INSERM U1021, Paris Sud University Centre de Recherche, Orsay, France
f Institute of Pharmacy, University of Hamburg, Hamburg, Germany
article info abstract
Article history: Insulin biosynthesis is an essential β-cell function and inappropriate insulin secretion and biosynthesis contrib-
Received 17 January 2014 ute to the pathogenesis of diabetes mellitus type 2. Previous studies showed that the dual leucine zipper kinase
Received in revised form 1 April 2014 (DLK) induces β-cell apoptosis. Since β-cell dysf