Chronic intermittent ethanol exposure reduces presynaptic dopamine neurotransmission in the mouse nucleus accumbens.pdf.pdf

G Model

DAD-5438; No. of Pages 7 ARTICLE IN PRESS

Drug and Alcohol Dependence xxx (2015) xxx–xxx

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Drug and Alcohol Dependence

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Chronic intermittent ethanol exposure reduces presynaptic dopamine


neurotransmission in the mouse nucleus accumbens

Anushree N. Karkhanis, Jamie H. Rose, Kimberly N. Huggins, Joanne K. Konstantopoulos,
∗

Sara R. Jones

Department of Physiology and Pharmacology Translational Center for the Neurobehavioral Study of Alcohol Wake Forest School of Medicine,

Winston-Salem, NC, USA

a r t i c l e i n f o a b s t r a c t


Article history: Background: Increasing evidence suggests that chronic ethanol exposure decreases dopamine (DA)

Received 19 September 2014

neurotransmission in the nucleus accumbens (NAc), contributing to a hypodopaminergic state dur-


Received in revised form

ing withdrawal. However, few studies have investigated adaptations in presynaptic DA terminals after

28 December 2014

chronic intermittent ethanol (CIE) exposure. In monkeys and rats, chronic ethanol exposure paradigms

Accepted 14 January 2015

have been shown to increase DA uptake and D2 autoreceptor sensitivity.

Available online xxx

Methods: The current study examined the effects of ethanol on DA terminal