Head motion during MRI acquisition reduces gray matter volume and thickness estimates.pdf.pdf

NeuroImage 107 (2015) 107–115
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NeuroImage
journal homepage: ate/ynimg
Head motion during MRI acquisition reduces gray matter volume and
thickness estimates
Martin Reuter a,b,c,d,⁎,1, M. Dylan Tisdall b,d,1,AbidQureshia,d, Randy L. Buckner b,d,
André . van der Kouwe b,d,BruceFischlb,c,d
a Massachusetts General Hospital, Department of Neurology, 55 Fruit Street, Boston, MA 02114, USA
b Massachusetts General Hospital, Department of Radiology, . Martinos Center for Biomedical Imaging, 149 Thirteenth Street, Suite 2301, Charlestown, MA 02129, USA
c Massachusetts Institute of Technology, Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA
d Harvard Medical School, 25 Shattuck St., Boston, MA 02115, USA
article info abstract
Article history: Imaging biomarkers derived from ic resonance imaging (MRI) data are used to quantify normal develop-
Accepted 2 December 2014 ment, disease, and the effects of disease-modifying therapies. However, motion during image acquisition
Available online 10 December 2014 introduces image artifacts that, in turn, affect derived markers. A systematic effect can be problematic since
factors of interest like age, disease, and treatment are often correlated with both a structural change and the
Keywords:
amount of head motion in the scanner, confounding the abili