letters to nature
Received 15 September; accepted 6 November 2000. Medical Research Foundation of Oregon (.) and the American Heart Association
(.).
1. Saier, M. H. Jr et al. Evolutionary origins of multidrug and drug-speci®c ef¯ux pumps in bacteria.
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expression of a multidrug ef¯ux transporter upon binding the transporter substrates. J. Biol. Chem. plexes have been deposited in the RCSB Protein database under accession code
269, 28506±28513 (1994). 1exj and 1exi, respectively.
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multidrug transporter. J. Bacteriol. 181, 5131±5133 (1999).
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that regulates expression of the us aureus multidrug ef¯ux pump QacA. J. Biol. Chem. 273,
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regulator of the Bacillus subtilis multidrug transporter Bmr.
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