Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr mice.pdf.pdf

Research Article
Hematopoietic overexpression of Cyp27a1 reduces
hepatic inflammation independently of 27-hydroxycholesterol
levels in LdlrÀ/À mice
Tim Hendrikx1,2, Mike . Jeurissen1,2, Veerle Bieghs1,2, Sofie . Walenbergh1,2,
Patrick J. van Gorp1,2, Fons Verheyen1,2, Tom Houben1,2, Yasmin Dias Guichot1,2,
Marion . Gijbels1,2, Eran Leitersdorf3, Marten H. Hofker4, Dieter Lütjohann5,
⇑
Ronit Shiri-Sverdlov1,2,
1Department of Molecular ics, ELMI Unit (CRISP) and Pathology, Nutrition and Toxicology Research (NUTRIM) and Cardiovascular
Research (CARIM), Institutes of Maastricht, University of Maastricht, Maastricht, herlands; 2Department of Molecular Cell Biology,
ELMI Unit (CRISP) and Pathology, Nutrition and Toxicology Research (NUTRIM) and Cardiovascular Research (CARIM), Institutes of Maastricht,
University of Maastricht, Maastricht, herlands; 3Department of Medicine, Hadassah-Hebrew University Medical Center,
Jerusalem, Israel; 4Department of Pathology & Laboratory Medicine, University Medical Center Groningen, University of Groningen,
Groningen, herlands; 5Institute of Clinical Chemistry and Clinical Pharmacology,
University of Bonn, Bonn, Germany
Background & Aims: Non-alcoholic steatohepatitis (NASH) is occurred even though plasma and liver levels of 27HC did not dif-
characterized by hepatic lipid accumulation and inflammation. fer betw