forever young 2017 kim baumann学术.pdf

该【forever young 2017 kim baumann学术 】是由【探春文档】上传分享，文档一共【1】页，该文档可以免费在线阅读，需要了解更多关于【forever young 2017 kim baumann学术 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。RESEARCHHIGHLIGHTSNatureReviewsMolecularCellBiology|Publishedonline5Jan2017;doi:.176AGEINGtheappearanceoftreatedmicewasimproved,andalthoughmiceprogressivelylostbodyweight,,adultstemcellpopulationsintheInvitrocellularreprogrammingfewerhistoneγ-H2AXfoci(amarkermuscleandhairfollicleswerereplen-throughtheexpressionofthefourofDNAdouble-strandbreaks)andished,andcardiovascularalterationstranscriptionfactorsOCT4,SOX2,reducedlevelsoftheDNAdamageandhistologicalchanges(intheskin,KLF4andMYC(OSKM)hasbeenresponseproteinp53bindingpro-spleen,kidneysandstomach)thatshowntoameliorateage-associatedtein?1(TP53BP1),,includingofage-related-stress-responsegenesFurthermore,hangesgeneexpressionprofiles,telomereandsenescence-associatedgenes,andthatwereseeninvitro,-reductionintheexpressionofstress-reprogrammingcanhavebeneficialgenspecies(indicativeofimprovedandsenescence-associatedgenes,).-Short-,theauthorsinvestigatedcanreversesomeaspectsofthearchitecture,-typeAtruncatedformoflamin?AMoreover,(H3K9me3)alossofproliferativecapacityofshort-termHutchinson?Gilfordprogeriasyn-andH4K20me3,whichareusuallypancreaticβ-cells,whichcanleadtodrome(HGPS),whichischaracter-alteredduringageing,,ofskeletalmusclemass(sarco-penia).OSKMinmiceTheauthorsusedamousemodeloftheauthorsfoundthatanincreaseTheauthorsobservedthatcycliccanreverseHGPSandgeneratedprogeriamiceinH3K9me3levelsprecededtheexpressionofOSKMin12-month--termexpressionofOSKMinnuclearenvelopedefectsandwasβ-cellpopulation,enhancedtheirur,indicat-recoveryfrompancreaticinjuryandprocessreversedseveralmolecularandcell-icremodellingmayamelioratedglucosetolerancefollow-,,thesecellshadofage--month-oldmicehadaSo,doesatemporaryinductionofgreatermuscleregenerationcapacityan-?AsreprogramminginvivohasTogether,theseobservationssug-beenpreviouslyshowntoinducegestthatpartialreprogrammingbytheformationofteratomasandcyclicshort-terminductionofOSKMthedevelopmentofcancer,-relatedofshort-,-ameliorationofage-,,1719?1733(2016)theauthorstreatedprogeriaFURTHERREADINGBenayoun,.,Pollina,&,:lives,startingat8-,593–610(2015)fotototo/,NATUREREVIEWS|MOLECULARCELLBIOLOGY?2017MacmillanPublishersLimited,.