特发性中枢性性早熟和特发性矮小女孩初潮后治疗方法与疗效.doc

特发性中枢性性早熟和特发性矮小女孩初潮后治疗方法与疗效比较
崔朝晖王继东
无锡市儿童医院江苏无锡 214023)
摘要:【目的】观察促性腺激素释放激素类似物(GnRHa)联合应用重组人生长激素(rhGH)治疗特发性中枢性性早熟(ICPP)和特发性矮小(ISS)女孩月经初潮后预测成年身高(PAH)的效果。【方法】5例ICPP女孩和7例ISS女孩分别联合应用GnRHa(80—100mg ·Kg-1,每隔28-32天肌肉注射一次),rhGH( IU·Kg-1·d-1),连续应用18个月,对其治疗前后的生长速度,按骨龄的身高标准差分值(HtSDSBA)以及PAH进行分析。【结果】联合应用后二组女孩生长速度明显加快,HtSDSBA增加,而PAH则明显延长,但两组之间的差异不明显。【结论】GnRHa 联合应用rhGH能明显加快这二组患儿的生长速度,促进身高年龄对骨龄的追赶以及改善预测成年的身高。
【关键词】月经初潮;性早熟;特发性矮小;促性腺激素释放激素;生长激素
中图分类号
Observation bined treatment of gonadotropin-releasing hormone analog with binant human growth hormone in girls with central precocious puberty and with idiopathic short stature.
Cui zhao-hui Wuxi children's hospital Wuxi Jiangsu 214023 China
Abstract:【Objective】To observe the effect bined treatment with gonadotropin-releasing hormone analog(GnRHa) and binant human growth hormone (rhGH) on predicted adult height (PAH) in girls with central precocious puberty (CPP) and with idiopathic short stature (ISS) respectively.【Method】five girls with CPP, seven girls with ISS were treatmented at GnRHa 80-100mg·Kg-1
every
28 to 32days, rhGH IU · Kg-1· d-1, for 18months at least. Comparisons of growth velocity, hight SDS for bong age (HtSDSBA) and PAH were performened before and after bined treatment at 12months and 18 months respectively.【Results】 During bined with rhGH therapy growth velocity increased significantly (P < ), Ht