奥氮平片FDA说明书.pdf

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HIGHLIGHTS OF PRESCRIBING INFORMATION • Efficacy was established with Symbyax (olanzapine and
fluoxetine bination) in adults; refer to the product label
These highlights do not include all the information needed to use for Symbyax.
ZYPREXA safely and effectively. See full prescribing information
for ZYPREXA. ------------------------ DOSAGE AND ADMINISTRATION -----------------------
ZYPREXA (olanzapine) Tablet for Oral use Schizophrenia in adults () Oral: Start at 5-10 mg once daily;
ZYPREXA ZYDIS (olanzapine) Tablet, Orally Disintegrating for Target: 10 mg/day within several
Oral use days
ZYPREXA IntraMuscular (olanzapine) Injection, Powder, For Schizophrenia in adolescents Oral: Start at -5 mg once daily;
Solution for Intramuscular use
() Target: 10 mg/day
Initial . Approval: 1996
Bipolar I Disorder (manic or Oral: Start at 10 or 15 mg once daily
WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS mixed episodes) in adults ()
WITH DEMENTIA-RELATED PSYCHOSIS Bipolar I Disorder (manic or Oral: Start at -5 mg once daily;
See full prescribing information plete boxed warning. mixed episodes) in Target: 10 mg/day
adolescents ()
• Elderly patients with dementia-related psychosis treated with
antipsychotic drugs are at an increased risk of death. Bipolar I Disorder (manic or Oral: Start at 10 mg once daily
ZYPREXA is not approved for the treatment of patients with mixed episodes) with lithium or
dementia-related psychosis. (, , ) valproate in adults ()
When using ZYPREXA and fluoxetine bination, also Agitation associated with IM: 10 mg (5 mg or mg when
refer to the Boxed Warning section of the package insert for Schizophrenia and Bipolar I clinically warranted)
Symbyax. Mania in adults () Assess for orthostatic hypotension
prior to subsequent dosing (max. 3
--------------------------- RECENT MAJOR CHANGES -------------------------- doses 2-4 hrs apart)