研究生英文文献汇报系列2.ppt

研究生英文文献汇报系列2.pptInfant Gut Microbiome Associated WithCognitive Development婴儿(2岁时)的认知发育与(特定种类的)肠道微生物有关
Biological Psychiatry, June 2017(online)
IF:
Yao xing,2018-01-02
Contens
Background
Objectives
Methods
Results
Strengths and limitations
Conclusions
Words
rodents(啮齿动物)
Gut colonization(肠道微生物定植)
MSEL: Mullen Scales of Early Learning(马伦早期学****量表)
16S ribosomal RNA amplicon sequencing(16s rRNA扩增子测序)
alpha diversity(α多样性: α多样性高,肠道菌群比较成熟)
the University of North Carolina at Chapel Hill(北卡罗来纳大学教堂山分校)
Co-works(共线/同现网络)
Metagenome Prediction(宏基因组学预测,利用基因组学的研究策略研究样品所包含的全部微生物的遗传组成及其群落功能)
Faecalibacterium(普氏菌)
Bacteroides(拟杆菌)
aceae(瘤胃球菌/疣微菌科)
Background
gut microbiome is plex microbial ecosystem that varies between individuals and may be a key modulator of neurodevelopment through the microbiome-gut-brain axis(肠脑轴).
rodents, experimental manipulations that alter the intestinal microbiota impact anxiety and depression-related behaviors .
humans, altered position of the gut has been reported in children with autism and adults with depression and is linked to childhood temperament and adult cognition.
studies have addressed when these relationships emerge or directly examined which brain regions may be involved.
relationship may exist between concurrent(同时发生的) gut colonization and brain development processes.
Objectives
this prospective, longitudinal study, the researchers tested whether the 1-year-old gut microbiome was associated with cognitive es at 1 and 2 years of age.
hypothesized that infant gut microbiome samples would cluster into groups munity similarity and that cognitive ability would differ between ,肠道菌群样本可以聚类为不同的组,而聚类到不同组的婴儿可能具有不同的认知能力
Methods
1. Study Population
Recruited 89 1-year-old infants (twins and singletons) from two prospective longitudinal studies of early brain development at the University of North Carolina at Chapel 、纵向研究
Exclusion criteria for the parent studies included fe