唐氏筛查在高龄孕妇中应用价值的探讨.doc

唐氏筛查在高龄孕妇中应用价值的探讨.doc唐氏筛查在高龄孕妇中应用价值的探讨徐群1孙洪丽2(1昆明市宜良县第一人民医院妇产科云南昆明652100)(2昆明市妇幼保健院围产保健中心云南昆明650028)【摘要】目的探讨高龄孕妇(≥35岁)进行唐氐筛查的价值及在产前诊断中的作用。方法对7854例15-20周的孕妇进行唐氏血清甲胎蛋白(AFP)和游离雌三醇(uE3)游离人绒毛膜促性腺激素(β-HCG)三联法检测,并随访所有唐氐筛查孕妇的妊娠结局。结果唐氐筛查孕妇7854例,检山高风险孕妇474例,%;其中高龄孕妇有520例,高风险高龄孕妇163例,%,高龄孕妇筛查阳性率明显高于适龄孕妇(P<)。随访妊娠结局:诊断唐氏儿8例,其中高龄孕妇5例,(唐氏筛查均为高风险)。结论高龄孕期行唐氏筛查,据筛查结果行产前诊断,可提高人口素质,减少出生缺陷儿发生率。【关键词】唐氏筛查高龄孕妇探讨【中图分类号】R173 【文献标识码】A【文章编号】2095-1752(2013)27-0147-02InvestigationoftheapplicationvalueofDown’ssyndromescreeninginhigh-agedprimiparaXuQun1 SunHongli2KunmingTheFirstPeople’sHospitalofYiliangCounty, Kunming,Yunnan 652100KunmingMaternalandChildHealthHospital,PerinatalHealthCareCenterKunming,Yunnan650028【Abstract】Objective:ToinvestigatethevalueofDown’ssyndromescreeninginthehigh-agedprimipara(≥35yearsold):totest7854womenof15-20weekspregnancywithDown’sserumalpha-fetoprotein(AFP)andfreefemalethreealcohol(uE3)freehumanchorionicgonadotropin(β-HCG)tripleassay,:Inthese7854cases,474pregnantwomenhadbeendetectedhavinghighriskindelivery,%,meanwhile,amongthose520womenwhoarehigh-aged,high-agedwomenwithhigh-riskare163,%showingpositiveresult,thehigh-agedpregnantwomenshowedahigherpotentialofbeingpositiveofDown&r