CD44v6和uPA 在胃癌组织中的表达及相关性研究.doc

CD44v6和uPA 在胃癌组织中的表达及相关性研究
(作者:___________单位: ___________邮编: ___________)

【摘要】目的:观察CD44v6和uPA 在胃癌组织中的表达情况,分析它们在各种组织类型及不同分化程度胃癌中的表达规律,探讨它们的异常表达与胃癌侵袭转移的关系。方法:采用免疫组织化学SP 法分别检测CD44v6和uPA 在67 例胃癌组织中的表达。结果: (1)67 例胃癌组织中CD44v6阳性表达34 例(%, uPA 阳性表达35例(%);(2)CD44v6、uPA 在低分化胃癌中的表达率均比高分化中的高;(3)有淋巴结转移者的CD44v6、uPA阳性率比无转移者显著增高;(4)早期胃癌组、%、%、%,差异有统计学意义()。uPA的阴性表达率也有统计学意义;(5)胃癌中CD44v6 和uPA 的表达呈正相关() 。结论:CD44v6、uPA 的表达均与胃癌的分化程度、浸润深度和淋巴结转移有关,二者在胃癌的浸润和转移过程中可能有协同作用。
【关键词】胃癌;细胞表面整合蛋白-6;尿激酶型纤溶酶原激活物;浸润;转移
[Abstract] Objective:To study the expression of urokinase-type plasminogen activator(uPA) and cluster of differentiation 44-6 on the infiltration and metastasis of gastric cancer and to investigate the relationship of their expression. Methods:Immunohistochemical technique (S-P method) was applied to detect CD44v6 and uPA in 67 cases of gastric cancer. Results:(1)Of the 67 cases gastric cancer, 34( %) were positive for CD44v6 , 35 (%) for uPA. The co-expression of CD44v6 and uPA was 26(%);(2)The CD44v6 positive rate in well differentiated carcinoma was higher than that in poorly one () ; The same result was concluded about uPA();(3)CD44v6 and uPA positive rates in the cases with lymph node metastasis were relatively higher than that without lymph node metastasis();(4)The differences of CD44v6 and uPA posit