影响原发性醛固酮增多症患者肾小球滤过率相关因素分析.pdf

新疆医科大学
硕士学位论文
影响原发性醛固酮增多症患者肾小球滤过率相关因素分析
姓名:曾健
申请学位级别:硕士
专业:内科学
指导教师:王新玲
2011-04
新疆医科大学硕士学位论文
影响原发性醛固酮增多症患者肾小球滤过率相关因素分析
研究生:曾健导师:王新玲教授/主任医师
摘要
目的:探讨原发性醛固酮增多症(PA)患者肾小球滤过率(GFR)状况及影响
其的相关危险因素。方法:选取确诊为的患者名,另择同期住院的原发
性高血压()患者名作为对照组,分别测定两组相关生化指标,根据 MDRD
公式估算肾小球滤过率:×血清肌酐值- ×年龄- ×(女性)
计算出两组肾小球滤过率();通过对 PA 组患者及 EH 组患者临床资料进行统
计分析,了解两组间 eGFR是否存在统计学差异,利用多元回归分析探讨影响 PA 患
者 eGFR 的危险因素。结果:( )分别对组及组血清肌酐值、血清胱抑素
进行两独立样本检验,结果显示两组间差异均存在统计学意义(< );对
组及组的 eGFR 进行两独立样本检验,结果显示两组间存在统计学意义
(< )。( )通过秩合检验对两组小时尿蛋白定量进行统计学处理,显示
组小时尿蛋白排泄明显高于组(<)。( )将血清胱抑素、小时
尿蛋白定量、血浆醛固酮浓度、甘油三酯等可能影响患者 eGFR 的相关因素进行
多元回归分析,结果显示血清胱抑素、小时尿蛋白定量、血浆醛固酮浓度及血
钠浓度与呈负相关,相关系数分别为、、、,回归方
程为: 血清胱抑素小时尿蛋白定量血浆醛固酮
浓度血钠浓度。结论: 患者 eGFR 低于患者;血清胱抑素、小时
尿蛋白定量、血浆醛固酮浓度、血钠与 eGFR 呈负相关。
关键词:原发性醛固酮增多症肾小球滤过率危险因素
新疆医科大学硕士学位论文
Analysing The Relative factors that influence glomerular
fitration rate in primary aldosteronism
Postguaduate:zengjian Supervisor:Porf. Wang Xinling
Abstract
Objective: TO analyze the risk factors related to low glomerular filtration rate (GFR)
in aldosteronism and paring the value of glomerular filtration rate between patients
with primary aldosteronism and with essential hypertension. Methods:189 patients with
PA were included in this study. The value of GFR was caculated by MDRD equation,
Clinical characteristics, such as the concentration of plasma aldosterone, triglycerides,
plasma basic glucose et al were assessed in 198 PA patients and 198 matched controls with
EH. The duration of disease, body mass index, blood pressure, concentration of creatnine,
GFR and Cysc protein of two groups were studied by two independt samples T test.
Regression analysis were used to find the risk factor of PA that influnced GFR. Results :
(1)both of plasm the concentration of creatnine (± VS ±)and
Cysc protein(±± in PA are higher than EH group.(P<);
eGFR was significant higher in EH patients than PA
patients(±24