四君子汤对脾气虚型慢性萎缩性胃炎大鼠胃黏膜血流量及血清sod(精).doc

【摘要】目的:研究四君子汤对脾气虚型慢性萎缩性胃炎的治疗作用及机理。方法:50只Wistar大鼠随机分为空白组、模型组、四君子汤高、中、低剂量治疗组,每组10只。将除空白组外的其余各组大鼠制成脾气虚型慢性萎缩性胃炎模型。灌胃后测定各组大鼠胃黏膜血流量(GMBF)和血清超氧化物歧化酶(SOD)、丙二醛(MDA)含量。结果:与模型组比较,四君子汤中、高剂量组胃黏膜血流量明显增加(P<<),四君子汤3个治疗组血清SOD含量明显升高,血清MDA的含量明显下降(P<<)。结论:四君子汤可能通过显著改善胃黏膜血流量,升高血清SOD含量、降低血清MDA含量来实现对脾气虚型慢性萎缩性胃炎的治疗作用。【关键词】四君子汤慢性萎缩性胃炎胃黏膜血流量超氧化物歧化酶二醛AbstractObjective:TostudytheeffectandmechanismofSijunzidecoctiononchronicatrophicgastritisratswithSpleen-:50Wistarratswererandomizedintoblankgroup,modelgroup,Sijunzidecoctiontreatmentgroup1(highdosage),group2(middledosage),group3(lowdosage)(n=10).ChronicatrophicgastritismodelratswithSpleen-,,thegastricmucosabloodflowwasincreasedinSijunzidecoctiontreatmentgroup2andgroup3(P<<),thecontentofserumSODwasincreasedandthecontentofserumMDAwasdecreasedin3Sijunzidecoctiontreatmentgroups(P<<).Conclusions:SijunziDecoctioncanincreasegastricmucosabloodflowandthecontentofserumSOD,decreasethecontentofserumMDA,whichmaybecontributetotreatingonchronicatrophicgastritisratswithSpleen-;chronicatrophicgastritis;gastricmucosabloodflow;SOD;MDA四君子汤出自宋代《太平惠民和剂局方》,是健脾益气的经典方剂,由人参、白术、茯苓、甘草组成,主治各种气虚证,临床上多用于治疗慢性消化系统疾病。本实验观察四君子汤对脾