骨髓间充质干细胞分化为心肌细胞过程中Wnt信号通路的作用研究.doc


骨髓间充质干细胞分化为心肌细胞过程中
Wnt 信号通路的作用研究#
宋春敬1,徐思慧2,孟海建2,范英昌2**
5
10
(1. 天津中医药大学实验教学部;
2. 天津中医药大学中医学院)
摘要:骨髓间充质干细胞(bone marrow derived mesenchymal stem cells,BM-MSCs)具有多
向分化潜能,可以应用于修复细胞、组织、器官的损伤,通过干细胞移植疗法治疗多种疾
-MSCs 在一定的条件下可以诱导产生心肌细胞(cardiomyocytes,CMs),为治疗心肌疾
,Wnt 信号通路发挥着非常重要的作用,
因此本文主要探讨 BM-MSCs 分化为 CMs 过程中 Wnt 信号通路所发挥的作用。
关键词:中西医结合医学;骨髓间充质干细胞;心肌细胞;Wnt 信号通路
中图分类号:R2031
15
The role of Wnt signaling pathway in the differentiation of
bone marrow-derived mesenchymal stem cells (BMSCs) into
Cardiomyocytes
SONG Chunjing1, XU Sihui2, MENG Haijian2, FAN Yingchang2
20
25
30
35
40
(1. Department of Experimental Teaching, Tianjin University of Traditional Chinese Medicine;
2. Chinese Medical College,Tianjin University of Traditional Chinese Medicine)
Abstract: Bone marrow-derived mesenchymal stem cells (BM-MSCs) are multipotent stromal
cells, which have been widely used in transplantation for the repair of cells, tissues ans in
various disease models. BM-MSCs can differentiate into a cardiomyocyte (CMs) phenotype in
vitro and in vivo under certain inducing conditions, which brings hope to the treatment of heart
diseases and improving cardiac function. Wnt signaling pathway plays a key role in the normal
cardiovascular development and tissue remodelling in the mature heart ,so we mainly discuss the
function of Wnt signaling pathway