2-(1H-苯并咪唑-2-基)-5-取代-1,3,4-噁二唑化合物的合成及抑菌活性有机化学.pdf.pdf

有机化学Chinese Journal anic ChemistryARTICLE * E-mail: ******@sdau. Received May 12, 2012; revised July 5, 2012; published online July 9, 2012. Project supported by the Natural Science Foundation of Shandong Province (No. ZR2009BM044).山东省自然科学基金(No. ZR2009BM044)资助项目. Chin. J. Org. Chem. 2012, 32, 2129~2133 ? 2012 Chinese Chemical Society & SIOC, CAShttp://sioc-/ 2129DOI: -(1H-苯并咪唑-2-基)-5-取代-1,3,4-噁二唑化合物的合成及抑菌活性纪增臣a刘峰a张泽远b李付博a姜林*,b(a山东农业大学植物保护学院泰安 271018) (b山东农业大学化学与材料科学学院泰安 271018)摘要以苯并咪唑-2-甲酸、水合肼、取代苯基异硫氰酸酯和取代苯甲酸等为原料, 经多步反应合成了16种2-(苯并咪唑-2-基)-5-取代苯基-1,3,4-噁二唑和2-(苯并咪唑-2-基)-5-取代苯胺基-1,3,4-噁二唑新化合物, 并考察了微波辐射对反应的影响. 产物结构利用IR, 1H NMR, 13C NMR和元素分析确证. 用生长速率法测试了目标化合物对番茄灰霉病菌和小麦菌核病菌的离体抑制活性, 结果表明3种化合物对番茄灰霉病菌有很高的抑制活性, , μg/mL, 活性高于对照药剂多菌灵(EC50 = μg/mL). 关键词苯并咪唑; 1,3,4-噁二唑; 合成; 抑菌活性Synthesis and Antifungal Activity of Novel 2-(1H-Benzimidazol-2-yl)-5-substituted-1,3,4-oxadiazole Derivatives Ji, Zengchena Liu, Fenga Zhang, Zeyuanb Li, Fuboa Jiang, Lin*,b(a College of Plant Protection, Shandong Agricultural University, Taian 271018)(b College of Chemistry and Material Science, Shandong Agricultural University, Taian 271018)Abstract Sixteen novel 2-(1H-benzimidazol-2-yl)-5-substituted phenyl-1,3,4-oxadiazoles and 2-(1H-benzimida-zol-2-yl)-5-substituted phenylamino-1,3,4-oxadiazoles were synthesized fr