肿瘤分子靶向治疗的思考-课件（ppt·精·选）.ppt

BATTLE PROGRAM BATTLE PROGRAM ? Biomarker-based Approach of Targeted Therapy for Lung Cancer Elimination. Waun Ki Hong et al ? Biomarker Analysis in Core Biopsy ? Select Adequate Target Therapy 未来的方向未来的方向?加强癌症基因分型及药物基因学研究, 寻找各种靶向治疗药物的适用或预测指标。? Treating tumors according to their molecular defects and their upgraded or downgraded signal transduction pathways. Clinical Predictors of Clinical Predictors of Gefitinib Gefitinib or or Erlotinib Erlotinib Efficacy in NSCLC Efficacy in NSCLC ? Never smoker ? Female gender ? Adenocarcinoma ? Bronchoalveolar adenocarcinoma ? Asian origin 肿瘤分子靶向治疗的思考肿瘤分子靶向治疗的思考中山大学肿瘤防治所管忠震分子靶向治疗研究的兴起分子靶向治疗研究的兴起?上世纪 70-80 年代,癌症生物学研究迅速发展,从分子水平了解肿瘤发生、发展的机制。? Scientific research has increasingly identified key ic events critical to specefic cancer development. Targeting Therapy Targeting Therapy ? A new generation of small molecules or MABs that rationaly designde to inhibit specific signal transduction or transcription pathways that are critical for cancer cell growth and survival. EGFR Blockade as Cancer therapy EGFR Blockade as Cancer therapy ? The EGFR autocrine pathways plays an important role in the development and progression of human epithelial cancer. ? EGFR activation triggers a cascade of signals leading to cell proliferation , production of antiogenic factors and promotion of invasion and metastasis. ? High expression of EGFR mon in a wide variety of human cancers and is generally associated with advanced disease and poor prognosis,and with resistance to hormone therapy,chemotherapy,or radiotherapy. EGFR Blockade as Cancer Therapy: EGFR Blockade as Cancer Therapy: J. J. mendelsohn mendelsohn ’’ s Hypothesis (Early 1980s) s Hypothesis (Early 1980s) ? The blockade of EGFR activation may inhibit cancr cell proliferation. ? Cancer cells may be selectively sensitive to EGFR inhibition as co