重组人表皮生长因子治疗儿童口腔溃疡临床观察.doc

重组人表皮生长因子治疗儿童口腔溃疡临床观察.doc重组人表皮生长因子治疗儿童口腔溃疡临床观察[摘要]目的:探讨重组人表皮生长因子(金因肽)治疗儿童口腔溃疡的疗效。方法:88例患儿随机分为实验组和对照组,实验组采用金因肽局部喷药,对照组给予碘甘油局部涂药,分组观察。采用随机平行对照实验,以创面愈合时间及疼痛消失时间为考察指标,比较rhEGF凝胶和碘甘油治疗口腔溃疡的疗效。完成可评估病例88例,其中实验组48例,对照组40例。两组均治疗至溃疡愈合或2周止,记录溃疡愈合时间和疼痛消失时间。结果:实验组愈合时间为(±)d,对照组为(±3・15)d,两组比较,有非常显著性差异();实验组和对照组疼痛消失时间分别为(4・8±1・9)d和(7・3±3・9)d,两组比较,有非常显著性差异()。结论:rhEGF凝胶对口腔溃疡创面具有明显的促进愈合作用,应用方便、安全。[关键词]重组人表皮生长因子(金因肽);儿童口腔溃疡;治疗[中图分类号]R788E文献标识码]A[文章编号]1673-7210(2009)05(c)-013-binanthumanepidermalgrowthfactorinthetreatmentoforalulcerinchildrenZHENGFang,CHENXiaopei(DepartmentofStomatology,WuhanChildren"sHospital,Wuhan430016,China)[Abstract]Objective:binanthumanepidermalgrowthfactor(rhEGF):(n=48)andcontrolgroup(n=40),thetestgroupwasgivenrhEGFgelandcontrolgroupwasgiveniodineglycerinuntiltherestorationoforalulcerorfor2weeks・Thehealingtimeoforalulcerwoundandtheachedisappeartimewererecorded・Results:Thehealingtimeoftestgroupandcontrolgroupwere(+)dand (+) drespectively(P<).Theachedisappeartimeoftestgroupandcontrolgroupwere(±)dand(±3・9)drespectively(P<).Conclusion:rhEGFgelcanpromotetherestorationoforalulcerwithmuchconvenienceandsafety・[Keywords]binanthumanepidermalgrowthfactor;Childoralulcer;Therapy表皮生长因子(epidermalgrowthfactor,EGF)是20世纪60年代由Cohen和Montalcini在研究鼠神经生长因子时发现的一