Imaging in the Acute and Sub-Acute Phase of Mild Traumatic Brain Injury Can We See the Difference.pdf

JOURNAL OF NEUROTRAUMA 30:2–10 (January 1, 2013)
ª Mary Ann Liebert, Inc. Original Articles
DOI: .2486
Multi-Modal ic Resonance Imaging
in the Acute and Sub-Acute Phase of Mild Traumatic
Brain Injury: Can We See the Difference?
Arnold Toth,1, * Noemi Kovacs, 2, * Gabor Perlaki,1,3,5 Gergely Orsi,1,3,5 Mihaly Aradi,3
Hedvig Komaromy, 3 Erzsebet Ezer,2 Peter Bukovics,2,5 Orsolya Farkas,4
Jozsef Janszky,1,5 Tamas Doczi,2,5 Andras Buki,2,5 and Attila Schwarcz2,5
Abstract
Advanced ic resonance imaging (MRI) methods were shown to be able to detect the subtle structural consequences
of mild traumatic brain injury (mTBI). The objective of this study was to investigate the acute structural alterations
and recovery after mTBI, using diffusion tensor imaging (DTI) to reveal axonal pathology, volumetric analysis, and
susceptibility weighted imaging (SWI) to detect microhemorrhage. Fourteen patients with mTBI who puted
tomography with negative results underwent MRI within 3 days and 1 month after injury. High resolution T1-weighted
imaging, DTI, and SWI, were performed at both time points. A control group of 14 matched volunteers were also
examined following the same imaging protocol and time interval. Tract-Based Spatial Statistics (TBSS) were performed
on DTI data to reveal group differences. T1-weighted images were fed into Freesurfer volumetric ana