BRAF基因突变在甲状腺乳头状癌中的应用.pptx

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目录 CONTENTS
相关文献回顾
BRAF基因
BRAF与PTC
文献精选
展望
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相关文献回顾
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BRAF文献回顾
BRAF Mutations in Hairy-Cell Leukemia
The BRAF V600E mutation was present in all patients with HCL who were evaluated
Implications for the pathogenesis, diagnosis, and targeted therapy
N Engl J Med June 16 2011;364:2305-15.；
毛细胞白血病
所有毛细胞白血病BRAF V600E发生了变异
可以用来研究发病机理、诊断、靶向治疗
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BRAF文献回顾
Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer
Cetuximab plus FOLFIRI compared with FOLFIRI alone reduced the risk of progression of metastatic colorectal cancerN
Engl J Med april 2,2009;360:1408-17.
转移性结直肠癌
西妥昔单抗合并 FOLFIRI 降低对KRAS突变转移性结直肠癌患者的疾病进展风险
2011版NCCN提出：具有BRAF突变的患者预后差，一线治疗后疾病进展的，利用西妥昔单抗治疗是无效的
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BRAF文献回顾
Improved Survival With Vemurafenib In Melanoma With BRAF V600E Mutation
Aberrant activation of the BRAF kinase occurs in 60% of melanomas, and although BRAF inhibitors have shown significant early clinical success
N Engl J Med 2011;364:2507-16.
黑色素瘤
在黑色素瘤中有60%患者发生BRAF V600E突变
发生BRAF V600E突变的患者经vemurafenib（威罗菲尼）治疗，患者的总生存率和无进展生存率分别提高（37%&26%）。但易产生耐药。
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BRAF基因介绍
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PTC中BRAF基因突变的分布
The worldwide prevalence of BRAF mutations in PTC
Endocrine-Related Cancer (2006) 13 455–464
文献结论
※ B-RAFV600E mutation was found in 99 out of 260 PTCs (38%)
※ The B-RAFV600E mutation was present in % of cases of classic PTC (85 out of 176), in % (nine out of 51) of follicular variants of PTC, in % (five out of 23) of other PTC variants and in none of the ten poorly differentiated tumors.
※The B-RAFV600E was correlated with an older age at diagnosis (P =)

Endocrine-Related Cancer (2006) 13 455–464
BRAF基因突变的致病机理
The model illustrates the two major signaling pathways, the PI3K/Akt an