《2-(2,6-二甲基苯胺基)-2-氧代乙酸促进的铜催化的芳基溴代物的羟基化》.pdf.pdf

有机化学 Chinese J0umal anIc Chemist吖 AF{TICLE 2.(2,6一二甲基苯胺基)一2一氧代乙酸促进的铜催化的芳基溴代物的羟基化刘向前口张慧榔蒋咏文鼬(。上海大学化学系上海200444) P中国科学院f:海有机化学研究所生命,ff机国家重点实验室上海200032) 摘要CuI/2一(2,).‘.,催化剂用量降虿2 m01%,,该催化体系还町用于促进芳香溴代物一锅法合成对称的芳香醚. 关键词铜;Ullmann反应;2.(2,);羟基化;酚 2-(2,6一DimethyIphenylamino)-2-oxoacetic Acid as an Efficient Prompter f6r theCOpper-CalaIyzed HydrOxylation Of AryI BrOmides Liu,Xiangqian 4 Zhang,Hui宰’口 Jiang,Yongwen奉,6 eDepnrtmen|Qf chemistry,Shnnghni UniverSily,Shnnghni 20044钠 C sld正K叫Lnborato猡可Bioo曙nnic nndNn陬mt Pmducts Chemislry,Shnnghdi|nsmHte可。毽dnic chem{st秽, Chinese Accldem,《sciences。shnnghdi 20003萄 Abstract CuI/2.(2,)一2一oxoaceticacid(DMPA0)as an e衔cientcatal”bination was used for 山ehydmxylation ofaryl catalyst loading low to2m01%and substituted phenols could beprepared inwide addition,bymodi分ing mixed solVent and base thesymmetrical dia叮l etherscouId besyntllesized conVen。 iently fbm a叫lbmmides. Keywords copper;UlIm￡mn reaction:2-(2,6-dimethylphenyIamino)-2‘oxoacetic acid;hydIDxylation,phenol 最近的研究发现,一些特殊配体在铜催化的卤苯羟基化反应中起到关键的作用,?,Ⅳ,Ⅳ-二甲摹乙二胺(DMEDA)?, l,lo一菲罗啉12|,【3J’ 41,8一羟皋喹哪啶【5】'【6l,,1和D- ,