丙氨酸谷氨酰胺.doc

A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients 对于重症病人的抗氧化剂和谷氨酰***的随机使用试验 Daren Heyland, ., John Muscedere, ., Paul E. Wischmeyer, ., Deborah Cook, ., Gwynne Jones, ., Martin Albert, ., Gunnar Elke, ., Mette M. Berger, ., ., and Andrew G. Day, ., for the Canadian Critical Care Trials Group B ACKGROUND Critically ill patients have considerable oxidative stress. Glutamine and antioxidant supplementation may offer therapeutic benefit, although current data are conflicting 重症病人有很大的氧化应激, 谷氨酰***和抗氧化剂可以提供很好的治疗效果, 尽管这些和最新的数据些矛盾。 Methods In this blinded 2-by-2 factorial trial, we randomly assigned 1223 critically ill adults in 40 intensive care units (ICUs) in Canada, the United States, and Europe who had an failure and were receiving mechanical ventilation to receive supple- ments of glutamine, antioxidants, both, or placebo. Supplements were started within 24 hours after admission to the ICU and were provided both intravenously and en- terally. The primary e was 28-day mortality. Because of the interim-analysis plan, aP value of less than at the final analysis was considered to indicate statistical significance. 在这个未知的 2x2 析因试验中,我们将 1223 名重症成年病人随机分配到加拿大,美国和欧洲的 40 个重症监护室里,这些病人都是因多器官功能衰竭而接受机械通气并且需要提供谷氨酰***, 抗氧化剂。补充品是在 24 小时后进入 ICU 行静脉注射和伤后提供。主要结果是 28 天死亡。由于临时研讨工作,P 值小于 的最终分析被认为是显示统计学意义。 Results There was a trend toward in