Springer - Dna Methylation Basic Mechanisms Current Topics In Microbiology And Immunology - 2006 - 3540291148.pdf

301
Current Topics
in Microbiology
and Immunology
Editors
. Compans, Atlanta/ia
. Cooper, Birmingham/Alabama
,Kyoto·, Philadelphia/Pennsylvania
F. Melchers, Basel · . Oldstone, La Jolla/California
, Oslo · M. Potter, Bethesda/Maryland
. Vogt, La Jolla/California · H. Wagner, Munich
W. Doerfler and P. Böhm (Eds.)
DNA Methylation:
Basic Mechanisms
With 24 Figures and 3Tables
123
Walter Doerfler, Prof. Dr. Walter Doerfler, .
Petra Böhm Universität Erlangen
Universität zu Köln Institut für Klinische
Institut für ik und Molekulare Virologie
Zülpicher Str. 47 Schlossgarten 4
50674Köln 91054 Erlangen
Germany Germany
e-mail: ******@uni-, e-mail:
p.******@uni- ******@-
Cover illustration: Methylation Profile of Integrated Adenovirus Type 12 DNA
Inthe genome of theAd12-transformedhamster cell line TR12, one copy of Ad12 DNA (green
line) and a fragment of about from the right terminus (red line) of the Ad12 genome are
chromosomally integrated (fluorescent in situ hybridization, upper left corner of illustration). The
integrated viral sequence has remained practically identical with the sequence of the virion DNA.
All 1634 CpG´s in this de novo methylated viral insert have been investigated for their methylation
status by bisulfite sequencing. A small segment of these data is shown at the bottom of the graph.
Open symbols indicate unmethylated CpG´s, closed symbols methylated 5-mCpG dinucleotides.
This figure has been prepared by Norbert Hochstein, Institute for Clinical and Molecular Virol-
ogy,Erlangen University and is based on data from a manuscript in preparation (N. Hochstein,
I. Muiznieks, H. Brondke, W. Doerfler).
Library of Congress Catalog Number 72-152360
ISSN 0070-217X
ISBN-10 3-540-29114-8 Springer Berlin Heidelberg New York
ISBN-13 978-3-540-29114-5 Springer Berlin Heidelberg New York
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