干扰素α-2b治疗大鼠子宫内膜异位症模型的研究.doc

干扰素α-2b治疗大鼠子宫内膜异位症模型的研究
【摘要】目的利用大鼠子宫内膜异位症动物模型,探讨干扰素在不同给药方式下对大鼠子宫内膜异位症的影响。方法将已成模大鼠按病灶相近原则分为5组:腹腔用药组(n=8)、皮下用药组(n=8)、丹那唑组(n=7)、腹腔对照组(n=4)和皮下对照组(n=4),在行干扰素和丹那唑治疗后的1和3周分批处死大鼠,观察移植物的生长情况并取其组织作病理检查。结果腹腔用药组和皮下用药组大鼠移植物体积均明显缩小,并且用药3周后与1周后相比,作用更明显。组织学检查,对照组异位子宫内膜呈增生状态,而腹腔用药组和皮下用药组呈萎缩状态。结论腹腔与皮下注射干扰素均可使大鼠异位子宫内膜逐渐萎缩退化,部分能使其完全消失,效果与丹那唑相比无明显差异。
【关键词】子宫内膜异位症干扰素疾病模型动物
Treatment of Experimental Endometriosis with binant Human Interferon-α-2b in Murine Models
LI Cuiming LUO Huizhen YIN Ying
Tutor: XIE Meiqing
【Abstract】 Objective To observe the effect of binant human interferon-α-2b on the endometriosis implants using the rat model. Methods Endometriosis was induced in mature female rats. They are divided into five groups. First: Intraperitoneal injection group (n=8),Second: Subcutaneous injection group (n=8), Third: Danazol group (n=7),Fourth: the control group of intraperitoneal injection(n=3),Fifth: the control group of subcutaneous injection (n=4);experimental groups were given binant human interferon-α-2b after the second laparotomy. The control groups were given saline .The third laparotomy was operated after therapy. Results The sizes of the endometriosis tissues in the experimental groups (first, second groups)were much smaller than that in the control groups (fourth, fifth groups);there were differences between the experimental groups and the control groups. Histological examinatio