精品PPT课件----Quality Control In Biological Databases.ppt

Data Quality Issues:Traps & Pitfalls
Ashok Kolaskar
Vice-Chancellor
University of Pune, Pune 411 007. India
******@unipune..in
Cancer cell growth appears to be related to evolutionary development of plump fruits and vegetables
Large tomatoes can evolve from wild, blueberry-size tomatoes. The ic mechanism responsible for this is similar to the one that proliferates cancer cells in mammalians.
This is a case where we found a connection between agricultural research, in how plants make edible fruit and how humans e susceptible to cancer. That's a connection nobody could have made in the past.
Cornell University News, July 2000
Size of Tomato Fruit
: A Quantitative Trait Locus (QTL) key to the Evolution of Tomato Fruit Size. Anne Frary (2000) Science, 289: 85-88
Single gene, ORFX, that is responsible for QTL has a sequence and structural similarity to the human oncogene c-H-ras p21.
Fruit size alterations, imparted by alleles, are most likely to be due to the changes in regulation rather than in sequence/structure of protein.
Genome Update: Public domain
plete Genomes: 59
Archaeal 9
Bacterial 36
Eukaryal 14
Ongoing Genomes: 335
Prokaryotic 203
Eukaryotic 132
Private sector holds
data of more than 100
finished & unfinished
genomes.
Challenges in Post-Genomic era: Unlocking Secretes of quantitative variation
For even after genomes have been sequenced and the functions of most genes revealed, we will have no better understanding of the naturally occurring variation that determines why one person is more disease prone than another, or why one variety of tomato yields more fruit than the next.
Identifying genes like is a critical first step toward attaining this understanding.
Value of Genome Sequence Data
Genome sequence data provides, in a rapid and cost effective manner, the primary information used by anism to carry on all of its life functions.
This data set constitutes a stable, primary resource for both basic and applied rese