脂连素抑制人前列腺癌细胞氧化应急 Adiponectin inhibits oxidative stress in prostate carcinoma cells.pdf

Prostate Cancer and Prostatic Diseases (2012), 1–8
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ORIGINAL ARTICLE
Adiponectin inhibits oxidative stress in human prostate
carcinoma cells
J-P Lu1,2, ZF Hou1,2, WC Duivenvoorden1,2, K Whelan1,2, A Honig1,2 and JH Pinthus1,2
1Division of Urology, Department of Surgery, McMaster University, Hamilton, Ontario, Canada and 2Department of Surgical
Oncology, Juravinski Cancer Centre, Hamilton, Ontario, Canada
BACKGROUND: Emerging data suggest that obesity increases the risk of aggressive prostate cancer (PC), but the
mechanisms underlying this relationship remain to be fully elucidated. Oxidative stress (OS) is a key process in the
development and progression of PC. Adiponectin, an adipocyte-specific hormone, circulates at relatively high levels in
healthy humans, but at reduced levels in obese subjects. Moreover, case–control studies also document lower levels of serum
adiponectin in PC pared with healthy individuals.
METHODS: Human 22Rv1 and DU-145 PC cell lines were examined for the generation of OS and detoxification of reactive
oxygen species after treatment with adiponectin. Normality was confirmed using the Shapiro–Wilk test and results were
analyzed using a one-way analysis of variance.
RESULTS: We demonstrate that adiponectin increased cellular anti-oxidative defense mechanisms and inhi