Endovascular Treatment for Acute Ischemic Stroke.pdf

T h e ne w engl a nd jour na l o f medicine
original article
Endovascular Treatment for Acute Ischemic
Stroke
Alfonso one, ., Luca Valvassori, ., Michele Nichelatti, .,
Annalisa Sgoifo, ., Michela Ponzio, ., Roberto Sterzi, .,
and Edoardo ardi, ., for the SYNTHESIS Expansion Investigators*
ABSTR ACT
Background
From the Stroke Unit and Department of In patients with ischemic stroke, endovascular treatment results in a higher rate of
Neurology (., ., .), the Neuro­ recanalization of the affected cerebral artery than systemic intravenous thrombo-
interventional Unit and Department of
Neuroradiology (., .), and the Bio­ lytic therapy. However, comparison of the clinical efficacy of the two approaches is
statistics Service and Hematology De­ needed.
partment (.), Niguarda Ca’ Granda
Hospital, Milan; the Stroke Unit and Methods
Department of Neurology, Carlo Poma
Hospital, Mantua (.); and the Epide­ We randomly assigned 362 patients with acute ischemic stroke, within hours
miology and Medical Statistics Section, after onset, to endovascular therapy (intraarterial thrombolysis with binant
Department of Health Sciences, Univer­
sity of Pavia, Pavia (.) — all in Italy. tissue plasminogen activator [t-PA], mechanical clot disruption or retrieval, or a
Address reprint requests to Dr. bination of t