Chronic effects of neuroendocrine regulatory peptide (NERP-1 and -2) on insulin secretion and gene expression in pancreatic β-cells.pdf.pdf

Biochemical and Biophysical munications 457 (2015) 148–153
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Biochemical and Biophysical munications
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Chronic effects of neuroendocrine regulatory peptide (NERP-1 and -2) on
insulin secretion and gene expression in pancreatic b-cells
Ji-Won Kim a, Marie Rhee a, Jae-Hyung Park b, Hideki Yamaguchi c, Kazuki Sasaki d, Naoto Minamino d,
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Masamitsu Nakazato c, Dae-Kyu Song b, Kun-Ho Yoon a,
a Department of Endocrinology and Metabolism, Convergent Research Consortium for Immunologic Disease, The Catholic University of Korea, Seoul 137-040, Republic of Korea
b Department of Physiology, Keimyung University School of Medicine, Daegu 700-712, Republic of Korea
c Neurology, Respirology, Endocrinology, and Metabolism, Div. of Internal Medicine, Faculty of Medicine, Univ. of Miyazaki, Kiyotake, Miyazaki 889-1692, Japan
d Department of Pharmacology, National Cardiovascular Center Research Institute, Fujishirodai, Suita, Osaka 565-8565, Japan
article info abstract
Article history: Neuroendocrine regulatory peptides (NERP-1 and -2) are novel amidated peptides derived from VGF, a
Received 6 December 2014 polypeptide secreted from neurons and endocrine cells through a regulated pathway. Dr. Nakazato Mas-
Available online 19 December 2014 amitsu reported that NERP-1 and -2 may have a local modulator function o