Estrogen restores brain insulin sensitivity in ovariectomized non-obese rats, but not in ovariectomized obese rats.pdf.pdf

METABOLISM CLINICAL AND EXPERIMENTAL 63 (2014) 851– 859
Available online at
Metabolism

Estrogen restores brain insulin sensitivity in
ovariectomized non-obese rats, but not in
ovariectomized obese rats
Wasana Pratchayasakul a, b, Nipon Chattipakorn a, b, Siriporn C. Chattipakorn a, c,⁎
a Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University,
Chiang Mai, Thailand
b Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
c Department of Oral Biology and Diagnostic Science, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand
ARTICLE INFO ABSTRACT
Article history: Objective. We previously demonstrated that obesity caused the reduction of peripheral
Received 29 October 2013 and brain insulin sensitivity and that estrogen therapy improved these defects. However,
Accepted 17 March 2014 the beneficial effect of estrogen on brain insulin sensitivity and oxidative stress in either
ovariectomy alone or ovariectomy with obesity models has not been determined. We
Keywords: hypothesized that ovariectomy alone or ovariectomy with obesity reduces brain insulin
High-fat diet sensitivity and increases brain oxidative stress, which are reversed by estrogen treatment.
Ovariectomy Materials/Methods. Thirty female rats were assig