Insulin receptor-related receptor as an extracellular pH sensor involved in the regulation of acid–base balance.pdf.pdf

Biochimica et Biophysica Acta 1834 (2013) 2170–2175
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Biochimica et Biophysica Acta
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Review
Insulin receptor-related receptor as an extracellular pH sensor involved
in the regulation of acid–base balance☆
Alexander G. Petrenko a,⁎, Sergey A. Zozulya b, Igor E. Deyev a, Dominique Eladari c,d
a Laboratory of Receptor Cell Biology, Shemyakin-Ovchinnikov Institute of anic Chemistry, Russian Academy of Sciences, Moscow 117437, Russia
b Enamine Ltd, 78 Chervonotkatska Street, Kyiv, 02094, Ukraine
c Inserm, UMRS 970, Centre de recherche (Paris centre de recherche cardiovasculaire), F-75015 Paris, France
d Département de Physiologie, HEGP, AP-HP, Université Paris Descartes, F-75015 Paris, France
article info abstract
Article history: Recent studies of insulin receptor-related receptor (IRR) revealed its unusual property to activate upon extra-
Received 9 October 2012 cellular application of mildly alkaline media, pH>. The activation of IRR with hydroxyl anion has typical
Received in revised form 16 November 2012 features of ligand–receptor interaction; it is specific, dose-dependent, involves the IRR extracellular domain
Accepted 19 November 2012
and is panied by a major conformational change. IRR is a member of the insulin receptor minifamily
Available online 7 December 2012
and has been lon