Lowered extracellular pH is involved in the pathogenesis of skeletal muscle insulin resistance.pdf.pdf

Biochemical and Biophysical munications 445 (2014) 170–174
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Biochemical and Biophysical munications
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Lowered extracellular pH is involved in the pathogenesis of skeletal
muscle insulin resistance
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Hiroki Hayata a,1, Hiroaki Miyazaki a,c,1, , Naomi Niisato a,c, Noriko Yokoyama a, Yoshinori Marunaka a,b,c,
a Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
b Department of Bio-Ionomics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
c Japan Institute for Food Education and Health, Heian Jogakuin (St. Agnes’) University, Kyoto, Japan
article info abstract
Article history: Insulin resistance in the skeletal muscle is manifested by diminished insulin-stimulated glucose uptake
Received 30 December 2013 and is a core factor in the pathogenesis of type 2 diabetes mellitus (DM), but the mechanism causing insu-
Available online 3 February 2014 lin resistance is still unknown. Our recent study has shown that pH of interstitial fluids was lowered in
early developmental stage of insulin resistance in OLETF rats, a model of type 2 DM. Therefore, in the
Keywords: present study, we confirmed effects of the extracellular pH on the insulin signaling pathway in a rat skel-
Insulin eta