Insulin resistant rats display enhanced rewarding effects of nicotine.pdf.pdf

Drug and Alcohol Dependence 140 (2014) 205–207
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Drug and Alcohol Dependence
journal homepage: ate/drugalcdep
munication
Insulin resistant rats display enhanced rewarding effects of nicotine
Janell R. Richardson a, Joseph A. Pipkin b, Laura E. O’Dell b, Arbi Nazarian a,∗
a Department of Pharmaceutical Sciences, Western University of Health Sciences, 309 East Second Street, Pomona, CA 91766, United States
b Department of Psychology, University of Texas at El Paso, 500 West University Avenue, El Paso, TX 79968, United States
article info abstract
Article history: Background: o use among persons with Type II diabetes exponentially increases negative health
Received 21 December 2013 consequences and mortality rates. It is especially troubling that diabetic persons who smoke have a
Received in revised form 26 February 2014 greater difficulty with o cessation pared to non-diabetic smokers. Diabetes is a metabolic
Accepted 25 March 2014
syndrome that consists of insulin resistance due to disruptions in insulin signaling. We have previously
Available online 5 April 2014
shown that insulin depletion enhances the motivational effects of nicotine.
Methods: The present study expands our previous work by examining whether insulin resistance, pro-
Keywords:
duced by a high-fat diet (HFD) regimen, enhances the rewarding effects