Insulin secretion abnormalities in exocrine pancreatic sufficient cystic fibrosis patients.pdf.pdf

JCF-01170; No of Pages 6
Journal of Cystic Fibrosis xx (2015) xxx–xxx
ate/jcf
Original Article
Insulin secretion abnormalities in exocrine pancreatic sufficient cystic
fibrosis patients☆
⁎
Jamie L. Wooldridge a, , Rhonda D. Szczesniak b,c, Matthew C. Fenchel b,c, Deborah A. Elder d
a Department of Pediatrics, St. Louis University School of Medicine, St. Louis, MO 63104, United States
b Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States
c Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States
d Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States
Received 27 May 2014; revised 23 February 2015; accepted 23 February 2015
Abstract
Background: The aim of this study is to assess insulin secretion in pediatric cystic fibrosis (CF) patients with exocrine pancreatic sufficiency.
Methods: Glucose and insulin responses during an oral glucose tolerance test (OGTT) were measured in 146 CF patients. Patients were divided
into exocrine sufficient (CF-PS) and insufficient (CF-PI) groups based on pancreatic enzyme usage and fecal elastase. A reference group included
healthy, non-diabetic subjects.
Results: All CF groups showed reduced insulin secretion as measured by insulinogenic