IRS1 gene polymorphisms Gly972Arg and Ala513Pro are not associated with insulin resistance and type 2 diabetes risk in non-obese Turkish population.pdf.pdf

Meta Gene 2 (2014) 579–585
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Meta Gene
IRS1 gene polymorphisms Gly972Arg and Ala513Pro
are not associated with insulin resistance and type 2
diabetes risk in non-obese Turkish population
Hilal Arikoglu a,⁎, Melda Aksoy Hepdogru a,1, Dudu Erkoc Kaya a, Aycan Asik a,
Suleyman Hilmi Ipekci b, Funda Iscioglu c
a Department of Medical Biology, Faculty of Medicine, Selcuk University, Konya, Turkey
b Department of Endocrinology, Faculty of Medicine, Selcuk University, Konya, Turkey
c Department of Statistics, Faculty of Science, Ege University, Izmir, Turkey
article info abstract
Article history: Insulin receptor substrate 1 (IRS1), plays a critical role in insulin signaling
Received 26 June 2014 and its control has an important place in the development of insulin
Received in revised form 23 July 2014 resistance. The tyrosine phosphorylation of IRS1 serves as docking
Accepted 30 July 2014 molecules for downstream effectors such as Phosphatidylinositol
Available online 24 August 2014
3-kinase and phosphotyrosine phosphatase-2. We focused on the
Gly972Arg and Ala513Pro variants of the IRS1 gene, since these specific
Keywords:
allelic variants are located near the Tyr-Met-X-Met (YMXM) motifs
IRS1 gene
İnsulin resistance around Tyr987 and Tyr612. Thus, we aimed to investigate the effects of
Type 2 diabetes Gly972Arg/Ala513