Metabolic syndrome, but not insulin resistance, is associated with an increased risk of renal function decline.pdf.pdf

Clinical Nutrition 34 (2015) 269e275
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Clinical Nutrition
journal homepage: ate/clnu
Original article
Metabolic syndrome, but not insulin resistance, is associated with an
increased risk of renal function decline
Youbao Li a, Di Xie a,c, Xianhui Qin a,c, Genfu Tang b, Houxun Xing b, Zhiping Li b,
Xiping Xu c, Xin Xu a,c,*, Fanfan Hou a,c,*
a Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China
b Institute of Biomedicine, Anhui Medical University, Hefei, China
c Guangdong Institute of Nephrology, Southern Medical University, Guangzhou, China
article info summary
Article history: Background & aims: The purpose of this study was to evaluate the effect of metabolic syndrome (Mets)
Received 9 November 2013 and insulin resistance (IR) on the risk of renal function decline (RFD) in a rural Chinese cohort.
Accepted 1 April 2014 Methods: A total of 2696 subjects aged 40e71 years with normal renal function were followed-up for 7
years. RFD was defined using the Kidney Disease: Improving Global e definition, ., a drop in
Keywords: estimated glomerular filtration rate (eGFR) category panied by a 25% or greater drop in eGFR from
Metabolic syndrome baseline or a sustained decline in eGFR of more than 5 mL/min/ m2/year.
Renal function decline
Results: During the 7-year follow-up, % of th