钛铌锆β钛合金低弹性模量内固定材料的生物相容性研究论文.doc

钛铌锆β钛合金低弹性模量内固定材料的生物相容性研究论文.doc钛铌锆β钛合金低弹性模量内固定材料的生物相容性研究论文
【摘要】目的]通过体内实验的方法对新型β型钛合金(TiNbZr)骨折内固定材料的生物相容性进行评价。[方法](1)改良的鼠气囊模型(the air pouch model):健康成年SD大鼠24只,皮下充气造模后将钛铌铣β型钛合金(TiNbZr)颗粒混悬液注入气囊,收集囊内液体采用ELISA方法测定IL6和TNFα,用囊壁组织学切片进行炎症细胞反应分级和囊壁厚度测量,并与传统的钛铅钒合金(Ti6Al4V)进行比较。(2)接骨板植入模型:将TiNbZr做成接骨板固定在兔的胫骨上,于手术后4、8、12、24、36周分别观察接骨板周围的纤维膜形成情况和TiNbZr骨界面骨结合情况,并与不锈钢接骨板比较。[结果](1)Ti6Al4V、TiNbZr两种颗粒注入气囊48 h后都能引起TNFα分泌量显著升高(P 005), alloys made of titanium, niobium and zirconium (TiNbZr) oduli of elasticity Its biopatibility in vivo is evaluated in this paper[Method](1) 24 SD rats odified air pouch model experiments Air the pouches and the TiNbZr particles  The liquid in the pouches ination All the results phasized in this procedure This time the control material ade the air pouches secret more TNFα than that of the control (P 005) Ti6Al4V particles made the effect more prominent than TiNbZr particles did (P 005) This effect enstruations experiments The thickness of the air pouches plantation the need beside the plates The “callus overlay the plate” phenomenon ed in the boneplates interfaces No soft tissue  The same direct integration alloys developed in this study have loodulus and high biopatibility both Its perfect biopatibility in vivo shoising material for internal fixation instruments
Key niobiumzirconium;biopatible materials;in vivo
作者自行研制了低弹性模量钛铌锆β型(TiNbZ